By Dr. Dan Sliva
Only Bioactive CBD is Effective
What is cannabidiol (CBD)?
CBD is the main non-psychoactive compound of hemp and does not have mind-altering side effects.
CBD is well-tolerated and safe for human consumption.
I had great results from it as an ultra-marathoner, so I thought I would test a few CBD products for their efficacy using bioactivity testing that my lab uses to test food and drug compounds.
The results were surprising to me – a very large variation in bioactivity among various CBD products on the market.
Back in 2016, I was training for an ultra-marathon and had an injury. My recovery and pain was frustrating, until I started to experiment with CBD on myself.
Some of the products seemed to work a little, and others didn’t work at all. As a scientist, this made me curious about why, and I decided to test them in my lab.
The variance in results is generally consistent with recent studies.. like this one: A recent cross-sectional study found that CBD is mainly used to treat chronic pain, arthritis/joint pain, anxiety, depression, insomnia, and headaches…. BUT….
Only 36% of CBD users confirmed positive effects of CBD [Corroon and Phillips].
Why some CBD products work and not others became perplexing to me. So I went and tested them
Because the bioassays in my lab are based on biological activity along with chemical composition, we are able to go beyond simply CBD content, and determine whether there are other components in a product may subtract or augment the activity of the primary component.
CBD is the main non-psychoactive compound of hemp and does not have mind-altering side effects.
CBD is well-tolerated and safe for human consumption.
I had great results from it as an ultra-marathoner, so I thought I would test a few CBD products for their efficacy using bioactivity testing that my lab uses to test food and drug compounds.
The results were surprising to me – a very large variation in bioactivity among various CBD products on the market.
Back in 2016, I was training for an ultra-marathon and had an injury. My recovery and pain was frustrating, until I started to experiment with CBD on myself.
Some of the products seemed to work a little, and others didn’t work at all. As a scientist, this made me curious about why, and I decided to test them in my lab.
The variance in results is generally consistent with recent studies.. like this one: A recent cross-sectional study found that CBD is mainly used to treat chronic pain, arthritis/joint pain, anxiety, depression, insomnia, and headaches…. BUT….
Only 36% of CBD users confirmed positive effects of CBD [Corroon and Phillips].
Why some CBD products work and not others became perplexing to me. So I went and tested them
Because the bioassays in my lab are based on biological activity along with chemical composition, we are able to go beyond simply CBD content, and determine whether there are other components in a product may subtract or augment the activity of the primary component.
Since CBD containing products are not regulated, and are not tested for potency, bioactivity or efficacy, it is unknown whether any CBD products contain other compounds in the CBD preparation that decreases or increases its effectiveness.
SO, I decided that I would validate these products.
Validated CBD must be tested for its efficacy in specific cell-based assays.
CBD from DSTest laboratories is tested and verified for its ability to reduce inflammation of immune cells and to suppress growth of human cancer cells.
SO, I decided that I would validate these products.
Validated CBD must be tested for its efficacy in specific cell-based assays.
CBD from DSTest laboratories is tested and verified for its ability to reduce inflammation of immune cells and to suppress growth of human cancer cells.
How does CBD work?
CBD effectiveness depends on CBD absorption/bio-availability. CBD is insoluble in water, therefore CBD absorption in the human body is low. Several studies demonstrated that only 8% of CBD is absorbed after oral administration. Oral co-administration of CBD with fats enhanced absorption of CBD by 3-fold, compared to lipid-free formulations. However, specific delivery method using nanoparticles/ethosomes can increase CBD delivery 100% when compared to an aqueous solution. Some CBD sellers are offering "water soluble CBD", however, this CBD modification DOES NOT increase CBD absorption/bio-availability. Only CBD in nanoparticles spheres has maximal absorption.
DSTest laboratories developed nanoparticle/ethosome technology to produce CBD with the average 100 nm size and maximal absorption/bio-availability of CBD - NanoHempTM. The MOST EFFECTIVE CBD products, with pain relieving efficacy, confirmed by satisfied customers, contain NanoHempTM.
CBD effectiveness depends on CBD absorption/bio-availability. CBD is insoluble in water, therefore CBD absorption in the human body is low. Several studies demonstrated that only 8% of CBD is absorbed after oral administration. Oral co-administration of CBD with fats enhanced absorption of CBD by 3-fold, compared to lipid-free formulations. However, specific delivery method using nanoparticles/ethosomes can increase CBD delivery 100% when compared to an aqueous solution. Some CBD sellers are offering "water soluble CBD", however, this CBD modification DOES NOT increase CBD absorption/bio-availability. Only CBD in nanoparticles spheres has maximal absorption.
DSTest laboratories developed nanoparticle/ethosome technology to produce CBD with the average 100 nm size and maximal absorption/bio-availability of CBD - NanoHempTM. The MOST EFFECTIVE CBD products, with pain relieving efficacy, confirmed by satisfied customers, contain NanoHempTM.
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- We test and certify your CBD/Hemp products for the real ACTIVITY – EFFECTIVENESS
- We develop the EFFECTIVE CBD/Hemp nanoparticles (NanoHempTM) for your brand
Inquiry for testing your products and production of NanoHempTM - contact us!
